New therapies for leukaemia

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Although childhood acute lymphoblastic leukaemia (ALL) can be successfully treated in about 80% of the cases, we do not understand why some patients fail therapy.
This project is focused on testing novel therapies including, lectins, novel sugar-based and natural product-like compounds, new versions of steroids and anthracyclines. Tests will determine the effects of these compounds on known pathways involved in ALL development and response.
In addition DNA damage induced pathways are being examined by measuring changes in protein levels and cell death or survival. This allows us to identify novel ways that can then be manipulated to prevent recurrence and develop more specific, less toxic, successful therapies. If successful, these novel treatments may also be applicable to other forms of cancer.


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