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Our Research > Past Research Projects

Our Research
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Since established we have funded over 30 different research project. Some have led to breakthroughs including the development of novel treatments currently in pre-clinical trials

Past Research

Combining EZH2 inhibition and Radiotherapy for the Treatment of Childhood Rhabdomyosarcomas

Every year over 60 children and teenagers in the UK are diagnosed with rhabdoymosarcoma (RMS), yet treatment regimes and survival rates have remained largely unchanged for decades. Radiotherapy is an important component of treatment for…

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Development of an assay to revolutionise childhood leukaemia research and diagnosis using ground-breaking sequencing technologies

The development of ground-breaking technologies to facilitate the introduction of a new era of whole genome sequencing will revolutionise childhood leukaemia research and diagnosis. Whole genome sequencing has identified many genomic abnormalities of clinical relevance…

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Target acute leukemia cells in hypoxic bone marrow microenvironment by suppressing mitochondrial metabolic remodelling

In childhood acute lymphoblastic leukemia (ALL), residual leukemic cells persisting in the bone marrow after the first 4 weeks of therapy are termed as minimal residual disease (MRD). These cells are presumed to resistant to…

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Understanding the complexity of miRNA-regulated pathways in medulloblastoma

Medulloblastoma (MB) is the most common malignant brain tumour in children. More than one third of children with MB do not survive and essentially 100% of survivors face high risk of recurrence and significant long-term…

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Pilot project to investigate the impact of adipokines on Acute Lymphoblastic Leukaemia (ALL) outcomes

Obesity is recognised by the World Health Organisation as a global epidemic. Many links have been made between obesity and poorer outcomes for patients diagnosed with a range of diseases, including cancer. In particular, obese…

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Investigating the potential role of CHD1L, a chromatin-remodelling factor involved in the DNA damage response, in childhood neuroblastoma

Neuroblastoma is a very serious cancer, comprising around one tenth of childhood tumours, with around 15 cases in 100 being incurable. Neuroblastoma is unusual as depending on the age of patient diagnosis, cure rates differ…

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Investigating n-3 PUFAs for potential adjuvant therapy in acute lymphoblastic leukaemia

Treatments for acute lymphoblastic leukaemia (ALL) typically involve chemotherapy, usually in combination with steroids. There remains a need to develop novel therapies or enhance existing approaches to treatment, especially in patients with relapsed disease. A…

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Effect of amino acids on response to drugs

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Monitoring amino acid levels in patients undergoing treatment for A.L.L.

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Improved activity when combining drugs

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Development of novel treatments

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mutations in calreticulin (CALR) gene in human cases of Acute Myeloid Leukaemia (AML) and Myeloproliferative neoplasms (MPS)

This project involves functional characterization of CALR mutations identified in the patient samples. The study will use FLAG tagged Calr protein to identify the sub-cellular localization of mutant Calreticulin. In addition using Co-IP technique it…

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