JOSH'S STORY
In February of 2021, Josh’s parents noticed he was getting very pale. What was originally thought to...
Read MoreTreatments for acute lymphoblastic leukaemia (ALL) typically involve chemotherapy, usually in combination with steroids. There remains a need to develop novel therapies or enhance existing approaches to treatment, especially in patients with relapsed disease.
A link between inflammation and cancer is established. Whereas acute inflammation is perceived as a physiologic protective response to injury, chronic inflammation has been found to mediate a wide range of diseases, including cancers. Chronic inflammation is known to be important as a moderator of tumorigenesis, affecting cellular processes of survival, proliferation, invasion, angiogenesis, metastasis and influencing responses to chemo- and radio-therapies. In addition, inflammation is considered to be a risk factor for the development of many types of cancers. Thus, there is a potential to employ anti-inflammatory agents to suppress NFκB or NFκB-regulated products for the adjuvant treatment of cancers.
Marine n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), typically derived by humans from consuming fish oils have received much attention for their anti-inflammatory properties and completely safe adjuvant therapeutic potential. There is already strong epidemiological evidence linking fish oil consumption with low incidence of cancers. Anticancer actions of n-3 PUFAs are poorly understood but a number of studies have demonstrated synergistic effects of n-3 PUFAs, particularly DHA, delivered as conjugates with a variety of anticancer drugs, improving drug efficacy by enhancing cellular uptake. The broad aim of the project is to investigate cytotoxic effects in human leukaemic cells of the n-3 PUFAs, EPA, DHA and a key metabolite Resolvin D1, alone and in combination with chemotherapeutic agents used for ALL treatment.
Grant Award – Kidscan Placement Student (2015-2016)
Funding Award – £2,000
Funding Awarded To – Dr Jeremy Allan
Research Location – University of Salford
Lead Researcher – Dr Jeremy Allan
In February of 2021, Josh’s parents noticed he was getting very pale. What was originally thought to...
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