Our Research > Past Research Projects

Our Research

Since established we have funded over 30 different research project. Some have led to breakthroughs including the development of novel treatments currently in pre-clinical trials

Past Research

An approach toward the total synthesis of (-)-Hispidospermidin

The novel terpenoid (-)-hispidospermidin 1 was isolated from a strain of Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. Reported in 1994, its structure was determined by both NMR studies of 1 and x-ray crystallographic analysis of…

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Environmental, poisons and contamination factors on cancer in children.

Heavy metals such as arsenic, lead, mercury, cadmium, cobalt and more are wildly known to be carcinogenic. This is the same for many pesticides and food enhancers. The toxicological pathways in many cases for these…

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Design and synthesis of new anticancer agents for the treatment of Leukaemia

Aromatic planar compounds are known to interact with DNA and some of the most widely used anticancer agents belong to this family known as intercalators. The project will synthesis a new family of agents and…

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Studying cancer stem cells and the identification of drugs that target these cells within cancers

Kidscan Technician Grant for 3rd floor technician, match funded with the School of Environment and Life Sciences Grant Award – Kidscan Pump Priming Grant (2016) Funding Award – £60,000.00 Funding Awarded to – Dr David…

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Validation of Shellfish Isolates (Glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for Children: GAG action on lymphocytes /Tregulatory cells

Previous research (Dr Dave Pye Kidscan), has identified exiting anti-tumour properties of isolated natural compounds from shellfish termed ‘glycosylaminoglycans’ (GAGs). It is not known if they are effective just on tumour cells or if they…

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The role of exocytosis for extracellular fate of miR-379/miR-656 miRNA cluster in cellularmodels of lung cancer

MiRNAs are small non-coding RNA which usually downregulate the expression of their target mRNAs(Bartel, 2004). The role of miRNA in cancer has been well documented(Peng & Croce, 2015). It was proposed that secreted extracellular miRNA…

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Self-esteem and children with CNS tumours

The personal response of children to treatment for cancer is important for their wellbeing during treatment and can impact on outcomes such as health-related quality of life, health status and psychological wellbeing afterwards. This study…

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Gold Nanoparticles as Radiation Enhancing Anticancer Medicine

The case for proton therapy in the UK is built around pediatric treatment. Radiation coupled with custom-designed nanoparticles offers an interesting promise for future anti-cancer therapeutics and there are already such nanoparticles in clinical trials…

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ABC transporters in neuroblastoma and the creation of a tumour-conducive

Understudied area that needs urgently addressing; hence this proposal. Grant Award – Kidscan Pump Priming Grant (2018) Funding Award – £5000.00 Funding Awarded to – Dr Ian Haslam Research Location – University of Huddersfield Lead…

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Synthesis and Evaluation of Phenothiazinyl Chalcones as Agents to target Rhabdomyosarcoma

Rhabdomyosarcoma is the third most prevalent children’s cancer and approximately 3% of children’s cancers are rhabdomyosarcomas with 250 US  and 60 UK children diagnosed a year (Ognjanovic et al., 2009; Macmillan Cancer Support, 2018). A…

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Developing Vascular Targeting Agents as a Method Combating Childhood cancers

This project is focused on the understanding and development of a new class of cancer drug targeting proteins involved in angiogenesis. These agents do not directly kill tumour cells – instead they destroy the blood…

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The wider anti-cancer potential of frankincense distillation by-products

For centuries, oils extracted from Frankincense – a resin harvested from trees in the genus Boswellia – have been used as a remedy in traditional medicine. Plants within this genus are known to produce Boswellic…

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