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Our Research > Past Research Projects

Our Research
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Since established we have funded over 30 different research project. Some have led to breakthroughs including the development of novel treatments currently in pre-clinical trials

Past Research

Interaction of NEIL3 with Fanconi Anaemia proteins in DNA Damage Repair.

NEIL3 is a DNA glycosylase that removes oxidatively damaged bases from single-stranded DNA. Its expression is normally cell cycle regulated, peaking during S/G2 phase and is expressed only in highly proliferating cells, including paediatric cancer…

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NEIL3 as a new target for cancer therapy

NEIL3 is a DNA glycosylase that has activity in vitro by releasing oxidised bases from DNA. Of interest to the field of cancer research, NEIL3 has been found to be highly expressed in cancer cell…

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Targeting Transcriptional Cyclin Dependent Kinases in medulloblastoma

Medulloblastoma (MB) is a highly aggressive embryonic tumour of the cerebellum and the most common malignant brain tumour of childhood (1). Despite a cure rate of approximately 70-75% among children aged ?3 years, MB survivors…

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Cyclin-dependent-Kinase inhibitors in medulloblastoma.

a:1:{i:0;s:900:Medulloblastoma (MB) is a highly aggressive embryonic tumour of the cerebellum and the most common malignant brain tumour of childhood (1). Despite a cure rate of approximately 70-75% among children aged ?3 years, MB survivors…

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A bioanalytical approach to elucidate biological response mechanisms of potential novel anti-leukaemic drug therapies in acute myeloid leukaemia cells

Gold nanoparticles are highly utilised for diverse biomedical applications owing to their low toxicity, ease of fabrication, flexible functionalisation, shape/size tuneability, and high visibility with Electron Microscopy. They are promising drug carriers and are excellent…

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Probing the biological effect of repurposed drugs in acute myeloid leukaemia cells using powerful biospectroscopic techniques

Acute myeloid leukaemia (AML) is an aggressive and common childhood cancer leading to a build-up of non-differentiated, dysfunctional cells from the myeloid lineage [1]. Patients can die within weeks of diagnosis and unfortunately the response…

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Probing the biological effect of repurposed drugs in acute myeloid leukaemia

Acute myeloid leukaemia (AML) is an aggressive and common childhood cancer leading to a build-up of non-differentiated, dysfunctional cells from the myeloid lineage [1]. Patients can die within weeks of diagnosis and unfortunately the response…

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Transcriptional inhibition of CDK6 resulting in apoptosis and cell cycle blockage in Osteosarcoma (SAOS-2) cell lines

Cell cycle inhibition is one of the most successful targets to reduce proliferation and induce apoptosis in cancer cells. A number of potential molecular targets for novel anticancer drug discovery have been identified in cell…

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Mutations in calreticulin (CALR) gene in human cases of Acute Myeloid Leukaemia (AML) and Myeloproliferative neoplasms (MPS)

This project involves functional characterization of CALR mutations identified in the patient samples. The study will use FLAG tagged Calr protein to identify the sub-cellular localization of mutant Calreticulin. In addition using Co-IP technique it…

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Effect of Reactive Oxygen Species on model cancer and healthy cell membranes: a molecular dynamics study

Effect of Reactive Oxygen Species on model cancer and healthy cell membranes: a molecular dynamics study Cold atmospheric plasma (CAP) is a new therapy recently developed for cancer treatment1-6. Studies have demonstrated that CAP is…

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Establishment of radiotherapy- and chemotherapy-resistant medulloblastoma cell lines.

Recurrent medulloblastoma (MB) is nearly universally fatal, and surgery at the time of recurrence is associated with significant morbidity and discomfort1. Presently, novel agents are tested in children with recurrent MB based on the unsubstantiated…

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Synthesis and evaluation of conformationally-restricted analogues of glycomimetics as possible anticancer agents

There is a need for treatments for childhood cancers which are more effective and produce less debilitating side-effects. One approach to drug treatment of cancer is to interfere with cell signalling pathways which transmit messages…

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