Screening novel sulfatase inhibitors for aggressive childhood Neuroblastoma

Neuroblastomas are a type of cancer that come from special nerve cells called neuroblasts, they are more common in babies and children. Extra copies of a gene called MYCN, also called N-myc are found in some patients with neuroblastomas and this means the disease is more aggressive, doesn’t respond as well to treatment and patients don’t live as long as those without the extra copies of the gene.

When extra copies of the gene are present, more of an enzyme called Sulf-2 is also produced, as this enzyme is outside of the cells it is a good target for new drug treatments. This study aims to test some of these potential new treatments in a cell model of neuroblastoma with the aim of finding new potential treatments to be tested in children with these hard to treat neuroblastomas.

Grant Award – Pump Priming Grant

Funding Award – £10,000

Funding Awarded to – Professor Jerry Turnbull

Research Location – University of Liverpool

Lead Researcher – Professor Jerry Turnbull


Professor Jerry Turnbull

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