Investigating the anti-cancer properties of Aspergillus fumigatus in neuroblastoma cells.

Neuroblastoma accounts for 10% of childhood cancer cases and an astonishing 15% of cancer fatalities in children [1]. Primary tumours typically arise in the adrenal glands often metastasising to major organs leading to a heterogeneous range of symptoms include abdominal distension, generalised skeletal pain, weight loss, malaise, anaemia, fever and irritability [2]. Treatment includes surgery and chemotherapy, but prognosis is poor with a 50% fatality rate in children diagnosed aged >1.The airborne fungus Aspergillus fumigatus secretes a vast range of metabolic products that show potent anti-cancer properties [3] including paclitaxel/taxol already being exploited clinically for a range of cancers. Of interest, TNP470, a fumagillin analogue was shown to prevent neuroblastoma angiogenesis and gliotoxin another metabolite was shown to inhibit neuroblastoma growth [4, 5]. These promising findings warrant further research into the therapeutic potential of Aspergillus.

Grant Award – Kidscan Student Placement (2019 – 2020)

Funding Award – £2000.00

Funding Awarded to – Dr Sara Namvar

Research Location – University of Salford

Lead Researcher – Dr Sara Namvar