JOSH'S STORY
In February of 2021, Josh’s parents noticed he was getting very pale. What was originally thought to...
Read MoreHGF/SF is a growth factor involved in epithelial cell replication and motility which has been strongly implicated in cancer progression and metastasis. It represents a potentially valuable extracellular target for therapeutic inhibition. A series of simple glycomimetics of the general form 1, based on heparin, have been discovered with selective inhibitory activity against HGF/SF activation of its specific signalling receptor MET.1 Some of these compounds have shown significant anti-metastatic ability in relevant cancer cell lines including the medulloblastoma cell line DAOY, where the potencies are comparable with the commercial MET inhibitor crizotinib. The glycomimetics show no cytotoxicity even at 100 ?mol. While these compounds have great potential as anti-metastatic agents the di and tetra sulfated molecules are highly polar and can be problematic in terms of purification and demonstrating purity.
Grant Award – Kidscan Student Placement (2018 – 2019)
Funding Award – £2000.00
Funding Awarded to – Dr Jim Wilkinson
Research Location – University of Salford
Lead Researcher – Dr Jim Wilkinson
In February of 2021, Josh’s parents noticed he was getting very pale. What was originally thought to...
Read MoreWhat a whopper of a night - Friday 20th May, our ambassador Isla's mum Jill and family hosted...
Read MoreWe want to say a huge thank you to Lee Mossop, former Captain of RFL Salford Red...
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