Our Research > Past Research Projects

Our Research

Since established we have funded over 30 different research project. Some have led to breakthroughs including the development of novel treatments currently in pre-clinical trials

Past Research

Development of novel treatments

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Self-esteem and children with CNS tumours

The personal response of children to treatment for cancer is important for their well being during treatment and can impact on outcomes such as health-related quality of life, health status and psychological well being afterwards….

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Developing Vascular Targeting Agents as a Method Combating Childhood cancers

This project is focused on the understanding and development of a new class of cancer drug targeting proteins involved in angiogenesis. These agents do not directly kill tumour cells – instead they destroy the blood…

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mutations in calreticulin (CALR) gene in human cases of Acute Myeloid Leukaemia (AML) and Myeloproliferative neoplasms (MPS)

This project involves functional characterization of CALR mutations identified in the patient samples. The study will use FLAG tagged Calr protein to identify the sub-cellular localization of mutant Calreticulin. In addition using Co-IP technique it…

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studying the problem of relapses within the central nervous system (CNS) in children with acute lymphoblastic leukaemia (ALL)

ALL is the commonest cancer of childhood and treatment related toxicity and relapse are important therapeutic challenges. To further improve outcome new, non-toxic, targeted therapies need to be developed. These may be targeted to the…

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Design and synthesis of new anticancer agents for the treatment of Leukaemia

Aromatic planar compounds are known to interact with DNA and some of the most widely used anticancer agents belong to this family known as intercalators. The project will synthesis a new family of agents and…

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Studies towards the asymmetric synthesis of novel antimitotic agents

A number of compounds are known which bind to the colchicine binding site on tubulin, preventing the assembly of microtubules and thus preventing cancer cells from dividing. The project will establish methodologies for the synthesis…

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Effects of a new class of leukaemia drug on normal myeloid leukocytes and lymphocytes

Assessing the effects of a new class of leukaemia drug on normal myeloid leukocytes and lymphocytes this includes neutrophils, monocytes, eosinophils, basophils, T-cells, B-cells and natural killer cells. The project will produce valuable data regarding…

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NEIL3 as a new target for cancer therapy

NEIL3 is a DNA glycosylase that has activity in vitro by releasing oxidised bases from DNA. Of interest to the field of cancer research, NEIL3 has been found to be highly expressed in cancer cell…

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